Daily oral tablet
Metformin ER
Extended-release metformin lowers the amount of glucose your liver releases and improves how your cells respond to insulin. Often paired with a GLP-1, sometimes used on its own.
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In the Diabetes Prevention Program, metformin reduced progression to type 2 diabetes by 31% over three years.
What is in it
Metformin hydrochloride, extended release.
How to take it
- Take once daily with your evening meal.
- Swallow whole. Do not crush or chew.
- Food reduces stomach upset noticeably.
- Stay consistent with timing day to day.
Why clinicians prescribe it
Well understood
Sixty years of data and one of the best-characterised safety profiles in medicine.
Works with a GLP-1
Different mechanism, so it stacks cleanly alongside semaglutide or tirzepatide.
Low cost
The least expensive prescription on our weight formulary.
Common questions
Typically modest, in the range of 4 to 7 pounds. It is most valuable for insulin resistance and blood sugar, with weight as a secondary benefit.
Important safety information
Not appropriate with significant kidney impairment. Tell your clinician before any procedure using contrast dye. Common side effects are digestive and usually settle within two weeks.
This page is not medical advice. Only a licensed clinician who has reviewed your history can decide whether this treatment is appropriate for you. Tell your clinician about every medication and supplement you take.
