Daily oral tablet
Naltrexone and Bupropion
A combination that acts on the brain pathways behind craving and reward eating, rather than on gastric emptying. Often the better fit for someone who eats in response to stress or habit rather than genuine hunger.
From $69/mo
Includes clinician visits, lab panel, medication, and unlimited messaging.
See if I qualifyNo charge until a clinician approves your plan.
Combination naltrexone and bupropion produces roughly 5 to 9% average body weight reduction alongside lifestyle support.
What is in it
Naltrexone hydrochloride and bupropion hydrochloride, extended release.
How to take it
- Start with one tablet in the morning and build up over four weeks.
- Take with food to reduce nausea, but avoid high-fat meals.
- Do not take in the evening, since bupropion can disrupt sleep.
- Never take with opioid painkillers.
Why clinicians prescribe it
Targets craving, not fullness
Useful when the problem is wanting to eat rather than being hungry.
No injections
A daily tablet with no needles, no refrigeration, and no supplies.
Mood is often affected too
Bupropion is an antidepressant, which some members find helpful alongside the weight effect.
Common questions
A GLP-1 makes you feel full sooner. This reduces how rewarding food feels and quiets cravings. Different mechanism, different experience, and a smaller average effect.
Important safety information
Contraindicated with opioid use, seizure disorders, uncontrolled hypertension, eating disorders, and abrupt alcohol or benzodiazepine withdrawal. Carries a boxed warning for suicidal thoughts in young adults. Blood pressure is monitored during treatment.
This page is not medical advice. Only a licensed clinician who has reviewed your history can decide whether this treatment is appropriate for you. Tell your clinician about every medication and supplement you take.
