Daily or as-needed oral tablet
Sertraline for Premature Ejaculation
Sertraline is an SSRI antidepressant, and delayed ejaculation is one of its most consistent side effects. Prescribed at a low dose for premature ejaculation, that side effect becomes the treatment.
From $26/mo
Includes clinician visits, lab panel, medication, and unlimited messaging.
See if I qualifyNo charge until a clinician approves your plan.
SSRIs reliably increase intravaginal ejaculatory latency time in controlled trials, with sertraline among the best studied.
What is in it
Sertraline hydrochloride.
How to take it
- Daily dosing: one low-dose tablet at the same time each day.
- As-needed dosing: take four to six hours before sex.
- Daily dosing works better for most men and takes two to three weeks to build.
- Do not stop abruptly after daily use. Taper with your clinician.
Why clinicians prescribe it
Well understood
Decades of data on the molecule, even though this specific use is off-label.
Two dosing options
Daily for consistency, or as-needed if occasions are infrequent and planned.
Inexpensive
A generic tablet, at a fraction of the cost of purpose-marketed alternatives.
Common questions
At the low doses used here, most men notice nothing. Tell your clinician if you have any history of depression or bipolar disorder, as it changes the calculation.
Important safety information
Do not combine with MAO inhibitors. Carries a boxed warning for suicidal thoughts in young adults. Report agitation, mood changes, or unusual bruising. Do not stop daily dosing abruptly, as discontinuation symptoms are common.
This page is not medical advice. Only a licensed clinician who has reviewed your history can decide whether this treatment is appropriate for you. Tell your clinician about every medication and supplement you take.
