Oral tablet, cycle days 3 to 7
Letrozole
Letrozole gently lowers estrogen for a few days, which prompts the brain to release more of the hormones that trigger ovulation. It has become the first-line choice for ovulation induction, particularly in women with PCOS, and is prescribed here after a clinician reviews your history and cycle.
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In the PPCOS II trial, letrozole produced higher ovulation and live-birth rates than clomiphene in women with PCOS.
What is in it
Letrozole, 2.5 mg to 5 mg per tablet.
How to take it
- Take once daily on cycle days 3 through 7, as prescribed.
- Use ovulation tests or tracking to time intercourse around day 12 to 16.
- Do not exceed the prescribed dose.
- Tell your clinician if a period does not arrive, so pregnancy can be confirmed.
Why clinicians prescribe it
First-line for a reason
Higher live-birth rates than clomiphene in PCOS, with a lower twin rate.
Only five days a cycle
A short course each month rather than a daily long-term medication.
Clinician guided
Prescribed and monitored after a review of your cycle and history.
Common questions
For most women, and especially with PCOS, letrozole is now preferred. It has better outcomes in trials and a lower chance of twins. Your clinician will confirm which fits your situation.
Important safety information
Only for use when not pregnant, so timing and cycle tracking matter. Hot flushes, fatigue, and headache are the most common effects. Prolonged use for ovulation induction should be supervised, and persistent difficulty conceiving deserves a full fertility workup.
This page is not medical advice. Only a licensed clinician who has reviewed your history can decide whether this treatment is appropriate for you. Tell your clinician about every medication and supplement you take.
